Advanced medical image analysis powered by AI

At APQ Health, we develop automated quantitative software powered by AI to analyze 3D medical images.

Evidence-driven AI coronary plaque analysis - Autoplaque

Backed by science:

100

peer-reviewed
publications

35

Academic
sites
Multicenter, international trials and studies including:
The Landmark SCOT-HEART clinical trial
Other Clinical trials including:
RAPID-CTCA, NXT, PACIFIC, PREFFIR, DIAMOND, EVOLVE, LodoCo 2, WARRIOR

APQ Health
- exclusive license of Autoplaque

FDA-cleared software for AI-powered quantification of coronary atherosclerosis - plaque buildup in the heart's arteries, characterization of dangerous plaque, and stenosis quantification, from CT angiography.
FDA approval

AI-enabled coronary plaque from CT Angiography

Autoplaque chart
Lin... Dey at al the Lancet Digital Health 2022

Quantitative plaque and heart attack: SCOT-HEART

Patients with larger total plaque volume and low-attenuation plaque burden are several fold likely to have subsequent heart attack.

Low-Attenuation NCP >4%: HR 4.65; 95% CI, 2.06-10.5; p<0.001

Williams,..., Newby, Dweck, Dey at al Circulation 2020

Deep learning-enabled coronary plaque: an international multicenter study

Autoplaque software visualization

DL vs Expert readers

ICC 0.922

Deep learning vs expert readers chart

Validated with IVUS using scan-specific thresholds

Agreement of
95%in a prospective, blinded,
Head-to-head comparison
with IVUS

Autoplaque vs invasive IVUS

ICC 0.95

Autoplaque results Chart
Image of Autoplaque patient report

Autoplaque

2803 patients, international
multicenter study

Image of Autoplaque patient report
Miller at al Circulation Cardiovascular Imaging 2024 https://www.ahajournals.org/doi/10.1161/CIRCIMAGING.124.016958

Prediction of heart attack

Plaque percentiles chart
Miller at al Circulation Cardiovascular Imaging 2024 https://www.ahajournals.org/doi/10.1161/CIRCIMAGING.124.016958

Selected publications (2020-2025)

  • Lin, …, Dey et al
    Deep learning-enabled coronary CT angiography for plaque and stenosis quantification and cardiac risk prediction: an international multicentre study.
    The Lancet Digital Health. 2022
  • Williams, …, Dey et al
    Low-Attenuation Noncalcified Plaque on Coronary Computed Tomography Angiography Predicts Myocardial Infarction: Results From the Multicenter SCOT-HEART Trial (Scottish Computed Tomography of the HEART).
    Circulation. 2020
  • Fiolet, …, Dey et al.
    Effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition in chronic coronary disease: a subanalysis of the LoDoCo2 trial.
    Heart
  • Han, ... Dey D, ..et al.
    Effects of Evolocumab on Coronary Plaque Composition and Microcalcification Activity by Coronary PET and CT Angiography.
    JACC Cardiovasc Imaging 2025
  • Kolossvary, ... Dey et al.
    Coronary Plaque Radiomic Phenotypes Predict Fatal or Nonfatal Myocardial Infarction: Analysis of the SCOT-HEART Trial.
    JACC Cardiovasc Imaging 2025
  • Tomasino,..., Dey et al.
    Coronary plaque characteristics quantified by artificial intelligence- enabled plaque analysis: Insights from a multi-ethnic asymptomatic US population.
    Am J Prev Cardiol 2024
  • Miller, …, Dey et al
    Patient-Specific Myocardial Infarction Risk Thresholds From AI-Enabled Coronary Plaque Analysis.
    Circ Cardiovasc Imaging. 2024
  • Flores Tomasino, …, Dey et al
    Reproducibility of artificial intelligence-enabled plaque measurements between systolic and diastolic phases from coronary computed tomography angiography.
    Eur Radiol. 2024
  • Lorenzatti, …, Dey et al
    Validation of a fully automated deep learning-enabled solution for CCTA atherosclerotic plaque and stenosis quantification in a diverse real-world cohort.
    J Cardiovasc Comput Tomogr. 2024
  • Tanisawa, …, Dey et al
    Quantification of Low-Attenuation Plaque Burden from Coronary CT Angiography: A Head-to-Head Comparison with Near-Infrared Spectroscopy Intravascular US.
    Radiol Cardiothorac Imaging. 2023
  • Suzuki, …, Dey et al
    Coronary Computed Tomography Angiography Findings of Plaque Erosion.
    Am J Cardiol. 2023
  • Williams, …, Dey et al
    Sex-Specific Computed Tomography Coronary Plaque Characterization and Risk of Myocardial Infarction.
    JACC Cardiovasc Imaging. 2021
  • Kwan, …, Dey et al
    Prediction of revascularization by coronary CT angiography using a machine learning ischemia risk score.
    Eur Radiol. 2021
  • Osborne-Grinter, …, Dey... et al
    Association of coronary artery calcium score with qualitatively and quantitatively assessed adverse plaque on coronary CT angiography in the SCOT-HEART trial.
    Eur Heart J Cardiovasc Imaging. 2021
  • Tzolos, …, Dey et al
    Repeatability of quantitative pericoronary adipose tissue attenuation and coronary plaque burden from coronary CT angiography.
    J Cardiovasc Comput Tomogr. 2021
  • Grodecki, …, Dey et al
    Noncalcified plaque burden quantified from coronary computed tomography angiography improves prediction of side branch occlusion after main vessel stenting in bifurcation lesions: results from the CT-PRECISION registry.
    Clin Res Cardiol. 2021
  • Lin, …, Dey et al
    Deep learning-enabled coronary CT angiography for plaque and stenosis quantification and cardiac risk prediction: an international multicentre study.
    The Lancet Digital Health. 2022
  • Williams, …, Dey et al
    Low-Attenuation Noncalcified Plaque on Coronary Computed Tomography Angiography Predicts Myocardial Infarction: Results From the Multicenter SCOT-HEART Trial (Scottish Computed Tomography of the HEART).
    Circulation. 2020
  • Fiolet, …, Dey et al.
    Effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition in chronic coronary disease: a subanalysis of the LoDoCo2 trial.
    Heart
  • Han, ... Dey D, ..et al.
    Effects of Evolocumab on Coronary Plaque Composition and Microcalcification Activity by Coronary PET and CT Angiography.
    JACC Cardiovasc Imaging 2025
  • Kolossvary, ... Dey et al.
    Coronary Plaque Radiomic Phenotypes Predict Fatal or Nonfatal Myocardial Infarction: Analysis of the SCOT-HEART Trial.
    JACC Cardiovasc Imaging 2025
  • Tomasino,..., Dey et al.
    Coronary plaque characteristics quantified by artificial intelligence- enabled plaque analysis: Insights from a multi-ethnic asymptomatic US population.
    Am J Prev Cardiol 2024
  • Miller, …, Dey et al
    Patient-Specific Myocardial Infarction Risk Thresholds From AI-Enabled Coronary Plaque Analysis.
    Circ Cardiovasc Imaging. 2024
  • Flores Tomasino, …, Dey et al
    Reproducibility of artificial intelligence-enabled plaque measurements between systolic and diastolic phases from coronary computed tomography angiography.
    Eur Radiol. 2024
  • Lorenzatti, …, Dey et al
    Validation of a fully automated deep learning-enabled solution for CCTA atherosclerotic plaque and stenosis quantification in a diverse real-world cohort.
    J Cardiovasc Comput Tomogr. 2024
  • Tanisawa, …, Dey et al
    Quantification of Low-Attenuation Plaque Burden from Coronary CT Angiography: A Head-to-Head Comparison with Near-Infrared Spectroscopy Intravascular US.
    Radiol Cardiothorac Imaging. 2023
  • Suzuki, …, Dey et al
    Coronary Computed Tomography Angiography Findings of Plaque Erosion.
    Am J Cardiol. 2023
  • Williams, …, Dey et al
    Sex-Specific Computed Tomography Coronary Plaque Characterization and Risk of Myocardial Infarction.
    JACC Cardiovasc Imaging. 2021
  • Kwan, …, Dey et al
    Prediction of revascularization by coronary CT angiography using a machine learning ischemia risk score.
    Eur Radiol. 2021
  • Osborne-Grinter, …, Dey... et al
    Association of coronary artery calcium score with qualitatively and quantitatively assessed adverse plaque on coronary CT angiography in the SCOT-HEART trial.
    Eur Heart J Cardiovasc Imaging. 2021
  • Tzolos, …, Dey et al
    Repeatability of quantitative pericoronary adipose tissue attenuation and coronary plaque burden from coronary CT angiography.
    J Cardiovasc Comput Tomogr. 2021
  • Grodecki, …, Dey et al
    Noncalcified plaque burden quantified from coronary computed tomography angiography improves prediction of side branch occlusion after main vessel stenting in bifurcation lesions: results from the CT-PRECISION registry.
    Clin Res Cardiol. 2021